Depression is cruel and insidious, invasive and hugely drawing down on people’s feelings of confidence and self worth. Its lacerations affect both body and mind. It can grip like a cancer and thrives because those afflicted feel the shame of leprosy creeping upon them and into their psyche. We have not yet come to discuss mental health issues openly and with confidence. This causes depression to prevail and dominate the shame side of human nature. We must overcome this barrier if depression is to be tackled with honest candour.